There is no specific rule on how many breakpoints a design should have. The rule of thumb is to make sure the design and content flow nicely on any viewport width. I will use two of my sites as examples: Web Designer Wall and Best Web Gallery. Web Designer Wall
On Web Designer Wall, I have 5 media queries: 1000px, 760px, 600px, 480px, and 320px. But in term of major layout changes, I only have three: 3-column with fixed side header, 2-column with top header, and a single column layout where the sidebar drops below content. The 2-column layout breakpoint is set at 1000px. The single column is set at 760px. The other breakpoints are necessary to ensure the content flows nicely across all breakpoints. Best Web Gallery
On Best Web Gallery, I have 3 media queries: 1240px, 800px, and 480px. In term of major layout changes, I have two: 4-column and a single column layout. In this case, I don't think it is necessary to have more layout breakpoints (ie. breaking the 4-column into 3-column or 2-column) because the post container doesn't break on small viewports.
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